Antioxidants reduce oxidative stress in follicular fluid of aged women undergoing IVF.
泰國(guó)試管嬰兒資訊：對(duì)于接受試管受精的高齡女性抗氧化劑可減少在*泡液中的氧化應(yīng)激反應(yīng)
春雨國(guó)際醫(yī)學(xué)團(tuán)隊(duì)翻譯的這篇文獻(xiàn)主要講述對(duì)于關(guān)于接受試管受精的高齡女性抗氧化劑可減少在*泡液中的氧化應(yīng)激反應(yīng)的關(guān)系。
BACKGROUND:
背景：
The status characterized by the imbalance between pro-oxidants and antioxidants molecules, defined as oxidative stress, has been suggested to be involved in the pathogenesis of subfertility in females. This study aims to evaluate the impact of a complete micronutrients supplementation on oxidative stress levels in follicular microenvironment as well as on in vitro fertilization (IVF) outcome.
我們將氧化劑和抗氧化劑之間的不平衡狀態(tài)定義為氧化應(yīng)激,這可能在女性生育能力低下的發(fā)病機(jī)制相關(guān)。春雨國(guó)際翻譯此文獻(xiàn)的目的旨在評(píng)估一個(gè)完整微量元素的補(bǔ)充對(duì)氧化應(yīng)激水平在濾泡微環(huán)境以及體外受精的結(jié)果的影響。
METHODS:
This preliminary study was conducted between January 2014 and July 2015 at the Siena University Hospital Infertility Clinic. Serum and follicular fluid were collected from infertile women aged?>?39 years who underwent two in vitro fertilization cycles: in the first cycle they were treated with GnRH-antagonist protocol and gonadotropins for controlled ovarian hyperstimulation, whereas in the second cycle ovarian stimulation protocol was associated to micronutrients supplementation, starting three months earlier. Protein oxidation levels and total antioxidant capacity in serum and in follicular fluid were evaluated in IVF cycles with or without micronutrients supplementation. Differences in IVF outcome parameters were statistically evaluated.
2014年1月至2015年7月之間的初步研究在錫耶納大學(xué)醫(yī)院不孕不育診所進(jìn)行。從> 39歲接受兩個(gè)體外受精周期不孕婦女血清和*泡液收集:在個(gè)周期對(duì)他們行促行線激素釋放激素和促性腺激素控制*巢過(guò)度刺激,而在第二個(gè)周期中*巢刺激協(xié)議相關(guān)的微量營(yíng)養(yǎng)素的補(bǔ)充從三個(gè)月前開(kāi)始。在血清和*泡液在體外受精周期中進(jìn)行評(píng)估蛋白質(zhì)氧化水平和總抗氧化能力或沒(méi)有補(bǔ)充微量元素。體外受精結(jié)果參數(shù)的差異在統(tǒng)計(jì)學(xué)上進(jìn)行評(píng)估。
RESULTS:
Two-dimensional electrophoresis analyses demonstrated that when patients assumed micronutrients before IVF cycles, follicular fluid and serum proteins were protected from oxidative damage. Comparable results were obtained when total antioxidant capacity was measured. Moreover, the mean number of good quality oocytes retrieved when patients received micronutrients supplementation was significantly increased.
二維電泳分析表明,在體外受精周期之前對(duì)病人補(bǔ)充微量營(yíng)養(yǎng)物質(zhì),*泡液和血清蛋白可免受氧化損傷。此外,優(yōu)質(zhì)*母細(xì)胞的平均數(shù)量可在病人補(bǔ)充微量元素后明顯增加。
CONCLUSION:
The additional treatment with micronutrients, starting three months before IVF cycles, protects the follicular microenvironment from oxidative stress, thus increasing the number of good quality oocytes recovered at the pick up.
從開(kāi)始試管嬰兒周期三個(gè)月前開(kāi)始利用微量元素,可抵抗氧化應(yīng)激反應(yīng)而保護(hù)濾泡微環(huán)境,從而增加優(yōu)質(zhì)*母細(xì)胞的數(shù)量恢復(fù)。
發(fā)表于2021-07-23 03:19:34
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泰國(guó)試管嬰兒資訊：對(duì)于接受試管受精的高齡女性抗氧化劑可減少在*泡液中的氧化應(yīng)激反應(yīng)
春雨國(guó)際醫(yī)學(xué)團(tuán)隊(duì)翻譯的這篇文獻(xiàn)主要講述對(duì)于關(guān)于接受試管受精的高齡女性抗氧化劑可減少在*泡液中的氧化應(yīng)激反應(yīng)的關(guān)系。
BACKGROUND:
背景：
The status characterized by the imbalance between pro-oxidants and antioxidants molecules, defined as oxidative stress, has been suggested to be involved in the pathogenesis of subfertility in females. This study aims to evaluate the impact of a complete micronutrients supplementation on oxidative stress levels in follicular microenvironment as well as on in vitro fertilization (IVF) outcome.
我們將氧化劑和抗氧化劑之間的不平衡狀態(tài)定義為氧化應(yīng)激,這可能在女性生育能力低下的發(fā)病機(jī)制相關(guān)。春雨國(guó)際翻譯此文獻(xiàn)的目的旨在評(píng)估一個(gè)完整微量元素的補(bǔ)充對(duì)氧化應(yīng)激水平在濾泡微環(huán)境以及體外受精的結(jié)果的影響。
METHODS:
This preliminary study was conducted between January 2014 and July 2015 at the Siena University Hospital Infertility Clinic. Serum and follicular fluid were collected from infertile women aged?>?39 years who underwent two in vitro fertilization cycles: in the first cycle they were treated with GnRH-antagonist protocol and gonadotropins for controlled ovarian hyperstimulation, whereas in the second cycle ovarian stimulation protocol was associated to micronutrients supplementation, starting three months earlier. Protein oxidation levels and total antioxidant capacity in serum and in follicular fluid were evaluated in IVF cycles with or without micronutrients supplementation. Differences in IVF outcome parameters were statistically evaluated.
2014年1月至2015年7月之間的初步研究在錫耶納大學(xué)醫(yī)院不孕不育診所進(jìn)行。從> 39歲接受兩個(gè)體外受精周期不孕婦女血清和*泡液收集:在個(gè)周期對(duì)他們行促行線激素釋放激素和促性腺激素控制*巢過(guò)度刺激,而在第二個(gè)周期中*巢刺激協(xié)議相關(guān)的微量營(yíng)養(yǎng)素的補(bǔ)充從三個(gè)月前開(kāi)始。在血清和*泡液在體外受精周期中進(jìn)行評(píng)估蛋白質(zhì)氧化水平和總抗氧化能力或沒(méi)有補(bǔ)充微量元素。體外受精結(jié)果參數(shù)的差異在統(tǒng)計(jì)學(xué)上進(jìn)行評(píng)估。
RESULTS:
Two-dimensional electrophoresis analyses demonstrated that when patients assumed micronutrients before IVF cycles, follicular fluid and serum proteins were protected from oxidative damage. Comparable results were obtained when total antioxidant capacity was measured. Moreover, the mean number of good quality oocytes retrieved when patients received micronutrients supplementation was significantly increased.
二維電泳分析表明,在體外受精周期之前對(duì)病人補(bǔ)充微量營(yíng)養(yǎng)物質(zhì),*泡液和血清蛋白可免受氧化損傷。此外,優(yōu)質(zhì)*母細(xì)胞的平均數(shù)量可在病人補(bǔ)充微量元素后明顯增加。
CONCLUSION:
The additional treatment with micronutrients, starting three months before IVF cycles, protects the follicular microenvironment from oxidative stress, thus increasing the number of good quality oocytes recovered at the pick up.
從開(kāi)始試管嬰兒周期三個(gè)月前開(kāi)始利用微量元素,可抵抗氧化應(yīng)激反應(yīng)而保護(hù)濾泡微環(huán)境,從而增加優(yōu)質(zhì)*母細(xì)胞的數(shù)量恢復(fù)。